Sunday, 22 October 2017

Should the fox hunting ban be lifted? [UK]

Fox hunting was banned in England and Wales in 2005 under the Hunting Act (2004) after already being banned in Scotland in 2002. Fox hunting first came around in the 1600s and was originally used as 'pest-control' to help reduce the number of livestock being killed by foxes. It is now considered by some as a traditional sport, although there  was a time when bear and bull baiting were as well. According to the RSPCA, 70-80% of UK residents support the ban, however, a YouGov poll in 2015 suggested that only 51% did. 

The Hunting Act 2004
Originally the ban was thought to be a simple and inexpensive way for politicians to gain popularity. However, it resulted in a drawn out process which cost the government over a million pounds and is thought to have had very little impact on animal welfare. Hunters on the other hand feel that it has outlawed a grand rural tradition and has somewhat confusing guidelines. The Telegraph claimed that 'The circumstances in which a fox could be killed were so confused that prosecutions have been thin on the ground.' Foxes can still legally be trapped or snared but must only be caught using these methods so that they can then be shot. It is legal to use two dogs to chase a fox out of hiding so that it can be shot but a pack of dogs can be used to flush the fox towards a bird of prey. Hunters will admit that some dogs may attack without an order but it is incredibly difficult to prove whether it was accidental or not. Most will admit that the law is confusing and needs to be improved for both sides. Tony Blair described fox hunting as 'banned but not quite banned at the same time'. 

Does the hunt have a purpose?
Many of the foxes that were caught by hounds were either cubs or weaker foxes which were less likely to survive. Hunters will argue that it allowed the weaker foxes to be culled and the stronger ones to survive, creating a healthier population. The hunt is supposedly used keep down the number of foxes in the area, however, research has shown that when a fox dies another fox will just take over that territory, meaning the population numbers will usually stay around the same. While some people claim foxes are a nuisance for killing livestock, a study that took place in Scotland suggested that foxes only account for 1% of lamb losses (but only two farms were used for this study). During hunting, it has been known for the hounds to kill livestock or pets. Foxes also benefit farms by killing rabbits which feed on crops. A study in 2003 estimated that this saves us £7 million a year. 

Is it cruel?
Before the ban, it was estimated that hunting resulted in the deaths of 20,000 foxes per year. This sounds like a lot, however, around 100,000 are killed every year just from road accidents. The same number of foxes can still be killed even after the hunting ban as it is still legal to shoot them. Many animal-rights activists will argue that this is a quicker and less cruel way to kill the foxes. In many cases this may be true, however if a fox is only injured by a gunshot then it can suffer for hours or even days before dying whereas they will usually be killed by dogs within seconds. The use of dogs is often seen as torturous as they will rip the foxes apart. As cruel as this may seem, this happens everyday naturally in the wild between other species. Foxes themselves will kill other animals such as rabbits and chickens, which will not die particularly quickly either. On the other hand, hunters have been accused of employing staff to block up any holes or escape routes before the hunt. This gives the fox an extremely unfair disadvantage and could be seen as the same principle as live feeding. 

The treatment of hounds
The other main cruelty accused in fox hunting is the treatment of the hounds. Dogs can also face severe injury during hunting as some foxes may fight back. It has also been claimed that any unwanted dogs will be disposed of.  Lynn Sawyer, an ex-hunter, claimed that it is 'normal' for dogs to be shot and then incinerated when they are not strong enough to hunt. She stated that she knew some dogs were even clubbed to death. Another ex-hunter, Clifford Pellow, said that there was a common use of negative reinforcement such as whipping and any dogs that did not turn out savage enough would be disposed of. Dogs that are kept closely in packs are more likely to spread disease amongst themselves.

Has the ban had any benefit?
Hunters have admitted that foxes are still killed by hounds while flushing them out, but claim that this only happens accidentally when the hounds attack without being ordered to. In May 2015 the League Against Cruel Sports found 16 fox cubs being held captive for hunting and in December later that year rescued another fox being kept ready for a hunt. This shows that, despite being illegal, the practice still continues and it is not uncommon for them to capture the foxes in advance for an easy hunt. Paul Tillsley (head of investigations for LACS) said that they have been covertly recording illegal hunts taking place and passing the evidence on to the police. In his experience he claimed that 'when hunts think they are not being watched, they get on as they always have done'. 

More Information:

Friday, 7 July 2017

The Immortal Jellyfish

Turritopsis dohrnii (not classified on the IUCN red list)

Although the species T. dohrnii was first discovered in 1883, its amazing ability to regenerate was not discovered until the 1990s. The immortal jellyfish was formally thought to be the Turritopsis nutricula, a similar but different species of jellyfish. The 'immortal jellyfish' is now classified as Turritopsis dohrnii, which is mainly found in the Mediterranean sea and the oceans surrounding Japan. The species is now being found more widely around the planet as they travel long distances by attaching themselves to cargo ships. Their preferred temperature is water around 22 degrees celcius, however, they are also found in colder water. They are made up of a clear bell-shaped structure filled with jelly. They have a bright red stomach which can be seen from the outside. This looks like a red cross from underneath. 
Red stomach cross-section
Once fully grown they are still incredibly small at 4.5mm in diameter and are only just visible without the use of a microscope. The first article published on the amazing ability of the immortal jellyfish classified it as a Turritopsis nutricula however this was corrected later on. The dohrnii has many similar features and genetic code to the T. nutricular and T. rubra. It has yet to be proven that these species also have the ability to 'regenerate' but it is thought that this could be possible. The dohrnii have nematocysts (also known as cnidoblasts or cnidocytes) on the tentacles which allow it to immobilise its prey before eating. These will not immobilise humans, but will cause a sting. Unlike other species, such as the box jellyfish, the dohrnii sting in not venomous. Jellyfish do not have a heart, brain or bones but the T. dohrnii do have light-sensitive receptors which allow it to detect light from the surface, helping it to recognise up and down directions.

The regeneration process
The process that the jellyfish undergoes to sustain its 'immortality' is known as transdifferentiation. Transdifferentiation is a type of metaplasia cell transformation which allows one type of specialised cell to turn into another. Although this process is found in other animal species such as newts, it is no where near as specialised as the process which occurs in the immortal jellyfish. The lens cells in the eye of a newt can become damaged. When this happens an iris cell within the eye can change into a stem cell. Stem cells have the ability to replicate any other cell and can then revert into a lens cell to replace the damaged/missing ones. In the immortal jellyfish, cells change directly into the required cell. The jellyfish can carry out this process in its entire being whereas a newt can not carry out differentiation in every cell of its body. The immortal jellyfish can even convert muscle cells into nerve or reproduction cells. 

 - Reproduction
The jellyfish are first born when a male ejaculates sperm into the water and some find their way into a female by chance. The fertilised eggs will stay on the surface of the female until they release free-swimming larvae known as planula
 - Planula
These planula have tiny cilia (hair-like structures) along their surface which allows a minimal amount of propulsion, but not enough for them to swim against currents.They will drift/swim through the water until they land on a firm surface such as the ocean floor or a rock. It will then anchor itself to this surface and transform into a polyp
 - Polyps
Polyp Stage
Polyps are cylindrical-shaped, stalk-like structures. They feed on small organisms such as zooplankton and plankton. Polyps use asexual reproduction to multiply. Eventually the polyps grow into a branch-like structure where the colony acts as a single organism (also known as hydroids). Polyps can live for 5 years and will eventually develop buds at its tips which will develop into medusae.
 - Medusae
The jellyfish that form from the buds of the polyps are also known as medusae. When the medusa buds off from the polyp it is only 1mm in diameter with just 8 tentacles. Once they are fully matured they are still incredibly small at about 4.5mm in diameter but they have 80-90 tentacles. It takes them about 2-4 weeks from budding to reach maturity. They will feed on plankton, tiny molluscs, larvae and fish eggs. 
 - Stimuli
The medusa will not automatically begin the regeneration process at sexual maturity. During its medusa stage the jellyfish may be exposed to environmental stress, injury, starvation, or it will eventually reach old age. This will stimulate the regeneration process. 
 - Retraction
Once the process is initiated, the medusa tentacles will retract and its body will begin to shrink in size. It will then drop down to the ocean floor and attach itself to a firm surface as a polyp again. The jellyfish then begins to mature all over again from the polyp stage. 


Transdifferentiation Cycle
Could these cells benefit humans?
A man named Shin Kubota is an associate professor at the Kyoto University in Japan, who has dedicated his life to studying the immortal jellyfish. These jellyfish are incredibly difficult to keep in captivity due to the fact that they have to be hand fed, given clean water daily, and must be constantly monitored. Shin Kubota is currently the only person who has managed to keep these jellyfish in captivity for a prolonged period of time. This species has inspired some scientists to research a new method of using stem cells to replace damaged cells, such as cancer cells, in humans. These jellyfish are more genetically similar to humans than simplistic species such as insects or worms. Despite this, the jellyfish are still a primitive species in comparison to humans. Without a brain, heart or bones it is much easier for these cells to perform transdifferentiation. We can not even be sure whether this process is possible in these organs. The process would not allow humans to revert back to the stage of being a baby but could be used in small collections of cells to repair damage. Overall, the structure of polyps and medusae are incredibly different to that of humans and this process is almost certainly not going to be seen in the near future. 

Are they immortal or just clones?
Although this process is described as 'immortality' it is actually closer to a cloning system that allows the jellyfish to replicate itself continuously, thus creating the possibility for immortality. It does not protect the species against other causes of death such as predation. This process can only be carried out during the medusa stage of life. Therefore, the species can die like any other animal from injury or disease during the polyp stage. 
The regeneration process has only been witnessed in captive jellyfish and never in the wild. This could suggest that it does not occur in their natural environment, however, 100% of specimens in captivity demonstrated the regenerative ability. Kubota stated that in two years, his colony re-birthed itself 11  times. The process is quite rapid, going from medusa to polyp in just three days. These jellyfish are so difficult to see that it is unlikely to observe them at the right time outside of captivity. They are likely to succumb to predation or disease during the polyp stage and are therefore highly unlikely to survive forever. They will be preyed upon by fish species such as tuna as well as other, larger species of jellyfish. Rebecca Helm from DeepSeaNews said that it is possible new clones may become more fragile from errors when copying the genetic code during the polyp stage. Mutations and errors in genetic code can occur during reproduction which could build up over time, causing the specimen to become weaker. It may eventually reach a stage where it can no longer complete the regeneration process, rendering it mortal after a certain life span. Due to the large number of varying factors and lack of observational research, it is impossible to determine an accurate lifespan for this species. 


More information:
-http://immortal-jellyfish.com/
-https://www.youtube.com/watch?v=2kLSiE-eNjw
-https://www.rsb.org.uk/membership/individual-membership/158-biologist/features/1510-everlasting-life-the-immortal-jellyfish


Thursday, 22 June 2017

Animal Testing - Pharmaceuticals [UK]

The UK regulations are considered some of the strictest animal testing regulations in the world. They are regulated by the Animal (Scientific Procedures) Act (1986) which was revised again in 2013. This act makes it illegal to use great apes such as gorillas and chimpanzees for testing, but the use of other primates is still legal. Animals such as dogs and primates are used the least due to the time and expense of keeping them in captivity. Rodents are used for about 80% of animal tests. Three licences must be obtained from the Home Office to carry out animal testing under the scientific procedures act. A project licence, personal licence, and an establishment licence. Each establishment must have appropriate accommodation and veterinary facilities to obtain a licence. The licence will specify which areas are suitable for certain procedures. For example some areas may be suitable specifically for dispatching animals after use, while other areas may only be used for certain types of testing. An establishment licence remains in force until it is revoked and should be reviewed annually. A personal licence is required by any person carrying out testing procedures. All researchers and technicians must have necessary training, skills and experience. They must carry out an accredited modular training course for each species being used and an additional course if they are going to carry out surgical procedures. The licence specifies where they can carry out procedures, the supervision in place, what types of procedures can be carried out and on which species. The licence remains in place indefinitely or until it is revoked, and is reviewed every 5 years. A project licence specifies the numbers and types of animals used, types of experiments carried out, purpose of the testing, and requires a certificate to confirm there are adequate facilities and staff for the procedures. A project licence can be issued for any length of time up to 5 years. After 5 years the holder must apply for a new licence. If the licence has been issued for less than 5 years the holder can apply to extend the licence up to 5 years. In 2015 approximately 570 project licences were granted and around 1400 inspections were carried out. 

Each project is also evaluated on the 3 R's:
Replacement: A project will only be granted a licence is there is no reasonable scientific alternative. They must prove that non-animal methods will not provide satisfactory or reliable results.
Reduction: They must use the smallest number of animals needed to give reliable results. It is the responsibility of the project licence holder to ensure there is no unnecessary or surplus breeding of animals. Procedures should not be carried out if there is data already available and sharing data should be encouraged to minimise the testing required. A project licence must justify any need for the duplication of tests (to confirm the accuracy of results). 
Refinement: Stress and pain must be reduced as much as possible in methods of testing, breeding, accommodation and care of the animals. Animals must be given pain relief where possible and when it will not disrupt the accuracy of results. Death should be avoided as an end-point when possible. A 'humane' end should be provided as soon as possible. 
Most animals will be euthanized after testing as they will be in too much pain and stress to justify keeping them alive. There are a few places that have been set up to rescue animals after lab testing, however, too many animals are used during testing to put them all up for adoption. Animals such as primates will have been born in captivity and can not be released into the wild. Often, the injuries and health problems sustained are so severe that it is kinder for them to be euthanized. 

More Information:

Sunday, 18 June 2017

Animal Testing - Household Products [UK]

Household Products
Household products include items such as washing up liquid, polish and air fresheners. On the 1st October 2015, the government implemented a ban on the testing of household products on animals. However, animals had not been used in the UK in this way since 2010 as it is usually the chemicals being tested, not the product as a whole. The government also included a 'qualified ban' for testing ingredients, where any ingredient expected to make up at least 50% of the final product can not be tested. All other ingredients and any chemicals that require testing under legislation such as REACH are still allowed. In addition to this, products that have been tested on animals abroad may still be imported. PETA described this new legislation as a 'step in the right direction' however the RSPCA believed 'it'll make little difference to animal welfare'. Since thousands of ingredients have already been tested and proved as safe, these will not need to be tested again. Testing of ingredients in household products is still allowed, despite cosmetic testing being banned, as substances used in these products (such as bleach) are more hazardous to consumers and the environment. They are also more likely to end up in the environment in larger quantities (bleach put down toilets, air fresheners in atmosphere etc). It is often questioned why new testing needs to be carried out when there are thousands of ingredients already proven to be safe. However, new ingredients still need to be tested as an attempt to find safer, less environmentally damaging chemicals. 

More Information:


Animal Testing - Cosmetics [UK]

Cosmetics
Cosmetic products are usually thought of as make up, however this also includes things such as shampoo, toothpaste and deodorantIn 2009 animal testing was banned for the use of cosmetic products in the EU. However, products could still be tested outside the EU then imported and sold in countries within it. This was changed in 2013 when new legislation was put in place to prevent the sale of cosmetic products, or products with ingredients that have been tested on animals, anywhere in the EU. Israel and India introduced similar legislation and India became the first country in Asia to ban animal testing for cosmetic products and their ingredients. Many people believe animal testing is now unnecessary as we already have thousands of products and ingredients that we know are safe. The RSPCA stated that 'there are more than enough cosmetic products available'. However, new chemicals can be tested under REACH (Regulation for Registration, Evaluation, Authorisation and Restriction of Chemicals). REACH is an EU regulation which carries out toxicity tests for chemicals on animals to ensure they are safe. New chemicals are required to be tested for the effect that they will have on workers who will be handling them and their environmental impact.They believe that hazardous chemicals can not be determined using only non-animal methods but require companies to share data so that the number of tests carried out will be limited. Although the products sold in the UK will not be tested on animals, products from the same company can be tested and sold outside the EU in countries such as USA and China, so some feel that buying from these companies is still indirectly funding animal testing. 

More Information:

Friday, 7 April 2017

Cavalier King Charles Spaniel (part 2)

Patella luxation
Patella luxation is a condition that involves repetitive dislocation of the patella (knee cap). It is seen in all types of dog but is most common in toy and miniature breeds of dog, such as the Cavalier King Charles Spaniel. It is also thought to be more common in females than males. Symptoms include abnormal movement in the hind limbs, lameness, skipping, and an abnormal posture while sitting. Clinical symptoms can be seen in dogs as early as four moths old. It is usually diagnosed during a physical examination from a veterinarian and is then confirmed by an x-ray. It is thought that it can lead to ruptured cranial cruciate ligament in 15-20% of cases. Dogs with intermittent or permanent lameness will be considered for surgery but most cases will be treated with pain killers, physiotherapy, and/or weight management. 

Keratoconjunctivitis sicca (KCS)
KCS (also known as dry-eye syndrome) is a disease that affects the precorneal tear film and prevents the production of moisture in the eye. It results in the inflammation of the cornea and tissues in the eye due to dryness. It is thought to affect around 1% of dogs. The Cavalier King Charles Spaniel is one of the breeds more commonly affected, along with breeds such as pugs and the English bulldog. Symptoms include redness and yellow/green discharge. If untreated it will eventually result in a cloudy film over the cornea and scarring around the eye. It can cause blurred vision, or loss of vision completely and causes the eyes to be more prone to infection. It can be diagnosed by a schirmer tear test which checks whether there is adequate tear production in the eye. KCS can not be cured and requires life long medication. Two commonly used medicines are cyclosporine and tacrolimus which must be administered in the eyes once or twice a day, every day. 

Syringomyelia
Syringomyelia MRI
http://cavalierhealth.org/syringomyelia.htm
Chiari-like malformation (CM) is a condition seen in cavaliers causing their brain to be too big for their skull. The back part of their skull puts pressure on the brain and some of the brain is squeezed out the back of the skull (foramen magnum). This is known as syringomyelia when the skull partially blocks the flow of cerebrospinal fluid from the brain, which is pushed through the central spinal canal. This causes a variation in pressure and creates fluid-filled cavities within the spinal cord, known as syrinx.
It is thought that this produces a pins-and-needles feeling around the head, neck and spine, while in severe cases it is thought to cause a burning sensation. Symptoms include being sensitive to touch, walking/moving slowly, problems jumping, scratching, phantom scratching, biting hind legs, or weakness in limbs. The symptoms seem to be worse during exercise, when excited, at night, and can even worsen due to changes in weather. It is thought that this is because of the changes in atmospheric pressure. It can be diagnosed by an MRI scan but there is no cure. Some dogs may have surgery to remove the back parts of the skull which are putting pressure on the brain. This will result in an improvement in about 80% of dogs, but 50% of these will have symptoms recurring within 2 years. In the most severe cases the dog will have to be euthanised as the condition is so painful. It is most commonly found in cavaliers and other toy breeds such as pugs, chihuahuas and yorkshire terriers. Symptoms will usually be seen after 2 years of age and a study showed that about 70% of cavaliers will have syringomyelia by the age of seven. It is a progressive illness which means it will get worse with time. It may end up destroying parts of the spinal cord, and the dog's legs will become progressively weaker. Some medications may be given to help limit the pain and reduce symptoms. Dogs with syringomyelia prefer to have their head elevated so keeping food and water bowls raised can help make them more comfortable. 

Video of cavalier with syringomyelia: 
https://www.youtube.com/watch?v=_UGp45LMCis